Platelet Mass Index as A New Factor in Tinnitus Etiology

 

Abstract

Introduction: Although there are numerous studies on the etiology and treatment of tinnitus, most have not provided a definitive conclusion. Vascular and hematological abnormalities play an important role in the etiology of tinnitus. In this study, we aimed to evaluate the usability of the platelet mass index as a new inflammatory marker in patients with tinnitus.

Material and Method: The detailed medical records (examination notes, drug use, radiological evaluations, audiological evaluations, and previous vascular-cardiac-autological surgical procedures) of 1,079 tinnitus patients presenting to our clinic between January 2019 and May 2020 were examined, and a retrospective hemogram evaluation was performed in 176 patients meeting the inclusion criteria in tinnitus group. As the control group, 190 people were selected from individuals that presented to the outpatient clinic without otologic complaints. Age, gender, erythrocyte (RBC), hemoglobin (HGB), neutrophil (NEU), lymphocyte (LYM), platelet (PLT) and mean platelet volume (MPV) were examined, and the neutrophil-lymphocyte ratio (NLR), plateletlymphocyte ratio (PLR) and platelet mass index (PMI) were calculated, and the results were compared between the tinnitus and control groups.

Statistical analysis and results: There were no statistically significant difference between the control and tinnitus groups in terms of mean age, gender, and RBC, NEU, LYM, PLR and NLR levels (p>0.05 for all). The HGB and MPV levels were significantly higher (p<0.001 for both) and the PLT level was significantly lower (p = 0.033) in the tinnitus group compared to the control group.

In addition, the PMI value of the tinnitus group was statistically significantly higher than that of the control group (p<0.001).

Discussion and conclusion: This study was the first to investigate PMI in tinnitus patients, and this index was found to be higher in this patient population. This supports the idea that PMI can be used as an inflammatory marker in tinnitus. PMI can reveal platelet functions more clearly since it provides the opportunity to simultaneously evaluate the volume and number of platelets. However, since the relationship of PMI with tinnitus severity was not examined in this study, further detailed studies are needed on this subject.

Keywords:Tinnitus; platelet mass index; inflammatory marker; mean platelet volume; platelet

 

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